陈蕾蕾研究员

简介：

陈蕾蕾研究员，硕士生导师，山东省泰山学者青年专家

教育经历：

1999/09-2003/06曲阜师范大学，16877太阳集团，本科，生物科学专业。

2003/09-2009/06 山东大学，16877太阳集团，博士，微生物学专业，导师：张玉忠教授。

2007/11-2008/12美国俄亥俄州立大学，生物化学系，联培，糖生物学专业，导师：Peng George Wang教授

工作经历：

2009/07-2013/06山东省农业科学院农产品研究所，职位：助理研究员。

2013/07-2019/07山东省农业科学院农产品研究所，职位：副研究员。

2019/08-至今 山东省农业科学院农产品研究所，职位：研究员。

2017-至今 16877太阳集团，16877太阳集团，职位：兼职硕士生导师。

研究兴趣，领域：

主要从事功能性微生物资源的挖掘与应用技术，包括定向选育具有不同活性的微生物菌种，建立菌剂及其活性成分的工业化发酵制备体系，研发微生物源功能性产品，助力农产品加工业的转型升级。具体研究方向：1、生物防腐保鲜技术研究与应用，2、功能性食品发酵技术的研究与应用

主持科研项目及人才计划项目情况：

1．国家重点研发计划课题，2017YFC1601404，食品微生物检验DNA相关参考物质体系研究与评价，2018/01-2021/12，385万元，子课题主持

2.  国家科技支撑计划子课题，2015BAD16B02，生物拮抗菌剂应用技术规程制定，2015/04-2018/03，186万元，主持

3.  国家自然科学基金青年科学基金项目，31100039，生防木霉SMF2产蛋白酶对植物病原真菌的拮抗机理研究，2012.01-2014.12，23万元，主持

4.  北京食品营养与人类健康高精尖创新中心开放基金，20182024，低值蛋白酶解活性肽的构效关系及抗氧化机制研究，2018.08-2020.08，20万元，主持

5.  山东省自然科学基金，ZR2016YL022，普鲁兰多糖高产高温菌株改造及产糖途径关键酶的性质研究，2016.11-2019.11，20万元，主持

6.  山东省农业重大应用技术创新课题，鲁财农指2015[16]号，发酵型灵芝全麦粉制备关键技术研究，2015.06-2017.05，20万元，主持

7. 山东省优秀中青年科学家奖励基金，BS2013SW039，拮抗芽孢杆菌NCPSJ7产新型抗菌蛋白的分离纯化及其抑菌机理研究，2013.10-2015.10，5万元，主持

8.  山东省农业科学院创新工程，CXGC2017B06，优势特色农产品产后增值关键技术， 2018.01-2020.12，111.5万元，首席专家

9.  山东省泰山学者青年专家项目，鲁政办字[2019]167号，2020.01-2024.12，100万元，主持

10.  山东省农业科学院青年英才项目，2016.01-2018.12，20.4万元，主持

代表性论文：

(1) Jinyu Yang, Yanhao Zhang, Shuangzhi Zhao, Qingxin Zhou, Xue Xin, Leilei Chen*. Statistical optimization of the medium components for pullulan production by Aureobasidium pullulans NCPS2016 using fructose and soybean meal hydrolysate. Molecules 2018, 23, 1334; doi:10.3390/molecules23061334

(2) Leilei Chen, Donglei Han, Yafei Zhai, Junhua Wang, Yifen Wang, Min Chen*, Characterization and Mutational Analysis of Two UDP-Galactose 4-Epimerases in Streptococcus pneumoniae TIGR4, Biochemistry (Moscow), 2018, 83:117-126

(3) Qingxin Zhou＃, Maorun Fu＃, Minhui Xu, Xiangyan Chen, Jiying Qiu, Fengli Wang, Ran Yan, Junhua Wang, Shuangzhi Zhao, Xue Xin, Leilei Chen*, Application of antagonist Bacillus amyloliquefaciens NCPSJ7 against Botrytis cinerea in postharvest red globe grapes, Food Science & Nutrition, 2020, 8:1499-1508.

(4) Ribang Wu#, Leilei Chen#, Dan Liu, Jiafeng Huang, Jiang Zhang, Xiao Xiao, Ming Lei, Yuelin Chen and Hailun He*, Preparation of Antioxidant Peptides from Salmon Byproducts with Bacterial Extracellular Proteases, Marine Drugs, 2017, 15, 4, doi:10.3390/md15010004

(5) Jiying Qiu#, Xiangyan Chen#, A. I. Netrusov, Qingxin Zhou, Danyang Guo, Xiaoyong Liu, Hailun He, Xue Xin, Yifen Wang, Leilei Chen*, Screening and  Identifying Antioxidative Components in Ginkgo biloba Pollen by DPPH HPLC-PAD Coupled with HPLC-ESI-MS2, Plos One, 2017, 12(1): e0170141. doi:10.1371/journal.pone.0170141

(6) Qingxin Zhou#, Leilei Chen#, Zhibin Wang, Junhua Wang, Shouqing Ni, Jiying Qiu, Xiaoyong Liu, Xiang Zhang, Xiangyan Chen*, Fast atrazine degradation by the mixed cultures enriched from activated sludge and analysis of their microbial community succession, Environmental Science and Pollution Research, 2017, 24:22152–22157

(7) Jiying Qiu#, Leilei Chen#, Qingjun Zhu, Daijie Wang, Wenliang Wang, Xin Sun, Xiaoyong Liu, Fangling Du*, Screening natural antioxidants in peanut shell using DPPH–HPLC–DAD–TOF/MS methods, Food Chemistry, 2012, 135:2366–2371

(8) Dan Liu, Jiafeng Huang, Cuiling Wu, Congling Liu, Ran Huang, Weng Wang, Tingting Yin, Xiaotao Yan, Hailun He*, Leilei Chen*. Purification, Characterization, and Application for Preparation of Antioxidant Peptides of Extracellular Protease from Pseudoalteromonas sp. H2, Molecules 2019, 24, 3373; doi:10.3390/molecules24183373.

(9) Min Chen#, Leilei Chen#, Yang Zou, Mengyang Xue, Min Liang, Lan Jin, Wanyi Guan, Jie Shen, Wenjun Wang, Lei Wang, Jun Liu, Peng George Wang*, Wide sugar substrate specificity of galactokinase from Streptococcus pneumoniae TIGR4, Carbohydrate Research, 2011, 346:2421-2425.

(10) Changbei Ma*, Miangjian Chen, Hailun He, Leilei Chen*. Detection of coralyne and heparin by polymerase extension reaction using SYBR Green I. Molecular and Cellular Probes, 2019, 10.1016/j.mcp.2019.101423.

(11) Leilei Chen#, Lijun Liu#, Mei Shi, Xiaoyan Song, Changying Zheng, Xiulan Chen, Yuzhong Zhang*. Characterization and gene cloning of a novel serine protease with nematicidal activity from Trichoderma pseudokoningii SMF2. FEMS Microbiology Letters, 2009, 299:135-142.

(12) Leilei Chen#, Min Zhang#, Donghua Zhang, Xiulan Chen, Caiyun Sun, Baicheng Zhou, Yuzhong Zhang*. Purification and enzymatic characterization of two β-endoxylanases from Trichoderma sp. K9301 and their actions in xylooligosaccharide production. Bioresource Technology, 2009, 100:5230-5236.

(13) Jiying Qiu, Xiangyan Chen, Huijiao Yan, Daijie Wang, Leilei Chen*. Isolation and purification of flavonoids from Ginkgo biloba pollen and their DPPH scavenging activities. Transactions of the Chinese Society of Agricultural Engineering, 2018, 10: 289-295.

(14) Jiying Qiu, Chaozhi Wei, Xiangyan Chen, Jinyu Yang, Xiang Zhang, Leilei Chen, Yifen Wang*, Dapeng Li*. Biotransformation of Ginkgo biloba pollen flavonoid glycosides by Lacbacillus perolens B2 and evaluation of antioxidant activities. Food Science, 2018, 39(21): 203-209.

(15) Binbin Xie, Qilong Qin, Mei Shi, Leilei Chen, Yanli Shu, Yan Luo, Xiaowei Wang, Jincheng Rong, Zhiting Gong, Dan Li, Caiyun Sun, Guiming Liu, Xiaowei Dong, Xiuhua Pang, Feng Huang, Weifeng Liu, Xiulan Chen, Baicheng Zhou, Yuzhong Zhang*, Xiaoyan Song*, Comparative Genomics Provide Insights into Evolution of Trichoderma Nutrition Style, Genome Biology and Evolution, 2014, 6(2):379-390.

(16) Haiyun Li, Yan Luo, Xiusheng Zhang, Weiling Shi, Zhiting Gong, Mei Shi, Leilei Chen, Xiulan Chen, YuZhong Zhang, Xiaoyan Song*. Trichokonins from Trichoderma pseudokoningii SMF2 Induce Resistance against Gram-negative Pectobacterium Carotovora subsp. Carotovora in Chinese cabbage, FEMS Microbiology Letters, 2014, 354: 75-82.

(17) Yang Zou#, Mengyang Xue#, Wenjun Wang#, Li Cai, Leilei Chen, Jun Liu, Peng George Wang, Jie Shen*, Min Chen*. One-pot Three-enzyme synthesis of UDP-Glc, UDP-Gal and their derivatives. Carbohydrate Research, 2013, 373:76-81.

(18) Yang Zou#, Zhigang Wu#, Leilei Chen, Xianwei Liu, Guofeng Gu, Mengyang Xue, Peng George Wang, Min Chen*, An Efficient Approach for Large-Scale Production of Sialyglycopeptides from Egg Yolks, Journal of Carbohydrate Chemistry, 2012, 31:436-446.

荣誉、奖励及参加学术团体的情况：

2018年，山东省留学人员回国创业奖

2018年，山东省科技进步二等奖，1/9

2019年，山东省“省直机关三八红旗手”

山东省欧美同学会，第一届青年委员会委员

山东省农业科学院留学人员联谊会，副秘书长