冉杰
日期： 2021/01/30 作者： 浏览量：
冉杰
个人简介：
冉杰 副教授，硕士生导师
邮箱：jran@sdnu.edu.cn
主要研究方向：纤毛是一种突出于细胞表面基于微管骨架的亚细胞结构，在环境感知、细胞运动等方面发挥重要作用。纤毛的组装和长度调控及纤毛稳态维持对于组织器管发育至关重要，并与多种人类重大疾病密切相关。然而，目前关于纤毛稳态调控的分子机制、纤毛在多种相关疾病中的功能及相关机制并不清楚。冉杰博士主要围绕纤毛稳态调控及纤毛相关疾病开展相关研究，主要研究方向为：1）纤毛的动态调控及相关分子机制；2）纤毛在组织器官发育和人类重大疾病发生发展中的功能及相关机制；3) 纤毛相关疾病新的治疗策略的开发和探究。
主持基金项目：
1. 国家自然科学基金专项项目：蓝光暴露影响视网膜稳态的分子机制，2023/01-2025/12，63万元，在研，主持。 2. 国家自然科学基金面上项目：UFL1调控纤毛组装和长度的分子机制， 2022/01-2025/12，58万元，在研，主持。 |
3. 国家自然科学基金青年项目：纤毛在早产儿视网膜早期病变中的病理学功能及分子机制, 2018/01-2020/12, 25万元,结题,主持。 |
4. 中国博士后面上项目（一等）：纤毛异常在高氧所致视网膜病变中的作用及机制，2016/09-2020/09，8万元，结题，主持。 |
代表性论文：
1.Jie Ran, Yao Zhang, Sai Zhang, Haixia Li, Liang Zhang, Qingchao Li, Juan Qin, Dengwen Li, Lei Sun, Songbo Xie, Xiaomin Zhang, Lin Liu, Min Liu, Jun Zhou*. Targeting the HDAC6-cilium axis ameliorates the pathological changes associated with retinopathy of prematurity. Adv Sci 2022, 26;e2105365. (一区TOP期刊，影响因子15.44) |
2.Jie Ran, Haixia Li, Yao Zhang, Fan Yu, Yunfan Yang, Chao Nie, Song Yang, Dengwen Li, Jun Zhou*, Min Liu*. A non-mitotic role for Eg5 in regulating cilium formation and sonic hedgehog signaling. Sci. Bull. 2021, 66 (16): 1620-1623. (一区TOP期刊，影响因子11.78) |
3. Jie Ran, Min Liu*, Jie Feng, Haixia Li, Huixian Ma, Ting Song, Yu Cao, Peng Zhou, Yuhan Wu, Yunfan Yang,Yang Yang, Fan Yu, Heng Guo, Liang Zhang, Songbo Xie, Dengwen Li, Jinmin Gao, Xiaomin Zhang, Xueliang Zhu, and Jun Zhou*. ASK1-mediated phosphorylation blocks HDAC6 ubiquitination and degradation to drive the disassembly of photoreceptor connecting cilia. Dev. Cell 2020, 53(3):287-299. (一区TOP期刊，影响因子12.27) |
4.Youguang Luo#, Jie Ran#, Songbo Xie, Yunfan Yang, Jie Chen, Shanshan Li, Wenqing Shui, Dengwen Li, Min Liu, Jun Zhou*. ASK1 controls spindle orientation and positioning by phosphorylating EB1 and stabilizing astral microtubules. Cell Discov 2016, 2: 16033. (一区TOP期刊，影响因子10.85) 5.Yunfan Yang#, Jie Ran#, Min Liu, Dengwen Li, Yuanyuan Li, Xingjuan Shi, Dan Meng, Junmin Pan, Guangshuo Ou, Ritu Aneja, Shao-Cong Sun, Jun Zhou*. CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Res 2014, 24(11):1342-53. (一区TOP期刊，影响因子25.61) 6.Jie Ran*, Jun Zhou*. Targeting the photoreceptor cilium for the treatment of retinal diseases. Acta Pharmacol Sin 2020, 41(11):1410-1415. (一区期刊，影响因子6.15) 7.Yunfan Yang#, Jie Ran#, Lei Sun#, Xiaodong Sun, Youguang Luo, Bing Yan, Tala, Min Liu, Dengwen Li, Lei Zhang, Gang Bao*, Jun Zhou*. CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism. Theranostics 2015, 5(7):656-66. (一区期刊，影响因子11.56) 8.Jie Ran, Yunfan Yang, Dengwen Li, Min Liu, Jun Zhou*. Deacetylation of alpha-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly. Sci Rep 2015, 5:12917 (二区期刊，影响因子4.38) 9.Ting Song#, Yunfan Yang#, Peng Zhou, Jie Ran, Liang Zhang, Xiaofan Wu, Wei Xie, Tao Zhong, Hongbin Liu, Min Liu, Dengwen Li, Huijie Zhao*, Jun Zhou*. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep 2022, 23(5):e54090. (一区TOP期刊，影响因子8.81) 10.Fan Yu, Song Guo, Te Li, Jie Ran, Wei Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, Xueliang Zhu, Jun Zhou*. Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications. Cell Res 2019, 29(2):171-173. (一区TOP期刊，影响因子25.61) 11. Fan Yu, Jie Ran, Jun Zhou*. Ciliopathies: Does HDAC6 Represent a New Therapeutic Target? Trends Pharmacol Sci 2016, 37(2):114-119. (一区TOP期刊，影响因子14.82) |
